N-hydroxy-4-((2-methyl-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)methyl)benzamide hydrochloride
Tubastatin A HCl
CAS: 1310693-92-5
Molecular Formula: C20H21N3O2.HCl
N-hydroxy-4-((2-methyl-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)methyl)benzamide hydrochloride - Names and Identifiers
N-hydroxy-4-((2-methyl-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)methyl)benzamide hydrochloride - Physico-chemical Properties
| Molecular Formula | C20H21N3O2.HCl |
| Molar Mass | 371.86058 |
| Melting Point | >221°C (subl.) |
| Solubility | Soluble in DMSO or Water. |
| Appearance | powder |
| Color | white to tan |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
| In vitro study | Tubastatin A is selective for all 11 HDAC subtypes, and the IC50 for HDAC6 is 15 nM, which is more than 1000 times that of all subtypes except HDAC8, which is about 57 times more selective for hdac8. The IC50 of Tubastatin A for HDAC8 was 854 nM. Tubastatin A has A protective effect on homocysteine (HCA)-induced neuronal cell death, which is dose-dependent from 5 μm, at 10 μm, the cells were substantially completely protected from damage. 100 ng/mL Tubastatin A enhances the inhibition of T cell proliferation by Foxp3 T-regulatory cells (Tregs) in vitro. Treatment of C2C12 cells with Tubastatin A resulted in abnormal myotube formation when α-tubulin was hyperacetylated early in the myogenesis process; However, myotube elongation occurred precisely when α-tubulin was hyperacetylated. Recent studies have found that in mouse ovarian cancer cell lines MOSE-E and MOSE-L, Tubastatin A treatment increases cell elasticity, this is the result of atomic force microscopy without drastic alteration of the actin microfilament and microtubule network. |
| In vivo study | Treatment with 0.5mg/kg Tubastatin A per day inhibits HDAC6-promoting T-regulatory cells (Tregs) in A variety of mouse models of inflammatory and autoimmune diseases such as experimental colitis, major histocompatibility complex-cardiac allograft rejection, and the like. The inhibitory activity. |
N-hydroxy-4-((2-methyl-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)methyl)benzamide hydrochloride - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29339900 |
N-hydroxy-4-((2-methyl-1,2,3,4-tetrahydropyrido[4,3-b]indol-5-yl)methyl)benzamide hydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.689 ml | 13.446 ml | 26.892 ml |
| 5 mM | 0.538 ml | 2.689 ml | 5.378 ml |
| 10 mM | 0.269 ml | 1.345 ml | 2.689 ml |
| 5 mM | 0.054 ml | 0.269 ml | 0.538 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: Tubastatin A HCl Visit Supplier Webpage Request for quotationCAS: 1310693-92-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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